Two men wake up at opposite sides of a dirty, disused bathroom, chained by their ankles to pipes. Between them lies a dead man loosely clutching a hand-held tape player and a handgun. Each finds a tape the perfect fit for the player in their back pocket. They play the tapes. One is threatened, the other isn't. But they have a task: One must kill the other by 6:00, or his wife and daughter will die. They find hacksaws in a toilet, and try to cut the chains, but it doesn't work. They are the two newest victims of the Jigsaw Killer. In a flashback, we learn of Amanda, a girl who falls victim to the Jigsaw Killer. On her head is a mask, which is hooked into her lower jaw. There is a timer on it. Only one key will unlock it, and that key is in the digestive tract of her cell mate who lies paralyzed on the opposite side of the room. If she doesn't unlock the mask in time, her lower jaw will be ripped wide open. She survives, but her cell mate doesn't. Through a series of flashbacks, we learn of more victims, and of the nearly-successful capture of the Jigsaw Killer, who doesn't actually kill his victims. Instead, he finds ways to make them kill either themselves, or each other, and he thinks the entire 'game' out perfectly, with no other ways out. Or so it would seem
Jigsaw returns. The brilliant mastermind behind the cruel identity is back for another round of his terrifically live or die games. When a new murder victim is found with all the signs of Jigsaws hand, Dectective Eric Matthews begins to investigate the full story and apprehends Jigsaw with a minimum lack of effort. Only for Jigsaw, getting caught is only one of the many parts of his plan. Eight more of his victims are already fighting for their lives its time for Eric Matthews to join, as the latest pawn on his vicious chalkboard.
Jigsaw has disappeared. Now aided by his new apprentice Amanda, the puppet-master behind the cruel, intricate games that have terrified a community and baffled police has once again eluded capture and vanished. While city detectives scramble to locate him, Dr. Lynn Denlon is unaware that she is about to become the latest pawn on his vicious chessboard. One night, after finishing a shift at her hospital, Lynn is kidnapped by the deranged Amanda and taken to an abandoned warehouse where she meets Jigsaw, aka: John Kramer, who's now bedridden and on the verge of death. Lynn is told that she must keep the madman alive for as long as it takes Jeff, another of his victims, to complete a game of his own. Racing against the ticking clock of Jigsaw's own heartbeat, Lynn and Jeff struggle to make it through each of their vicious tests, unaware that Jigsaw and Amanda have a much bigger plan for both of them...
Jigsaw and his apprentice Amanda are dead. Now, upon the news of Detective Kerry's murder, two seasoned FBI profilers, Agent Strahm and Agent Perez, arrive in the terrified community to assist the veteran Detective Hoffman in sifting through Jigsaw's latest grisly remains and piecing together the puzzle. However, when SWAT Commander Rigg is abducted and thrust into a game, the last officer untouched by Jigsaw has but ninety minutes to overcome a series of demented traps and save an old friend or face the deadly consequences.